I am on a MacBook Pro using OS 10.6.2 Snow Leopard. I purchased this scanner on Overstock in Mar 2010. It was incredibly easy to set up and to use. Here's what I did: Plugged in the scanner using the provided USB cable; Put a picture on the scanner; Launched Image Capture, the scanning software included w Snow Leopard; Clicked Scan in Image Capture. Note that I did not install or attempt to install the Canon software provided in the box. The image scanned just fine and dropped right into my Pictures folder (you also have the option of dropping it into iPhoto, Mail, etc.) This is an excellent, small, low-volume scanner for use with a Mac.