When I opened these sheets, they had a very strong, awful chemical odor that made my hands itch just taking them out of the package. So I washed them and put them on the bed; the first night, they were fine; the next, the smell came back and in the morning my skin was irritated and even tingly. I washed them twice again -- once with vinegar (saw that tip online); let them soak then washed them with lots of detergent a second time. They came out smelling like my fabric softener and I put them back on the bed. No chemical odor or irritation and they were very pleasant to sleep on. However, the next night, I detected a slight chemical odor again. Thinking I was being over-sensitive about it, I slept on them but the next morning the chemical smell was back and stronger and again, my skin was irritated and tingly. At this point, I will probably be returning them, but am upset as I was very pleased with the pattern, color and feel of these sheets. I just can't take this returning odor and am afraid because of the skin irritation issue.