I use this drive on my Macbook Pro to run VMware virtual machines. No issues at all, and there are no noticeable performance differences between this drive and the internal drive when running virtual machines.
The drive is great! Tons of storage! Only negative is it makes some noticeable noise while it's being used. I have several external drives that are mostly silent. The drive is hooked up to my tv entertainment PC and is about 7 feet from my couch and the sound of it searching for files is clearly audible. For me though it's not a deal breaker
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